Regulation of Immune Responses to Mycobacteria bovis by a Paracrine Mechanism of Vitamin D Signaling in Cattle
We provide evidence that T-cell responses to Mycobacteria bovis are suppressed by the production of 1,25-dihydroxyvitamin D3 in monocytes and B-cells from cattle. Current vitamin D requirements for cattle are solely based on the classical endocrine mechanism of vitamin D signaling that regulates calcium homeostasis and should be re-evaluated to account for vitamin D signaling mechanisms in the immune system.
Keywords: ASL R2601
How to Cite:
Nelson, C. D. & Beitz, D. C. & Reinhardt, T. A. & Lippolis, J. D., (2011) “Regulation of Immune Responses to Mycobacteria bovis by a Paracrine Mechanism of Vitamin D Signaling in Cattle”, Iowa State University Animal Industry Report 8(1). doi: https://doi.org/10.31274/ans_air-180814-646