@article{air 5658, author = {Corwin D. Nelson, Donald C. Beitz, Timothy A. Reinhardt, John D. Lippolis}, title = {Regulation of Immune Responses to Mycobacteria bovis by a Paracrine Mechanism of Vitamin D Signaling in Cattle}, volume = {8}, year = {2011}, url = {https://www.iastatedigitalpress.com/air/article/id/5658/}, issue = {1}, doi = {10.31274/ans_air-180814-646}, abstract = {<p>We provide evidence that T-cell responses to <em>Mycobacteria bovis</em> are suppressed by the production of 1,25-dihydroxyvitamin D<sub>3</sub> in monocytes and B-cells from cattle. Current vitamin D requirements for cattle are solely based on the classical endocrine mechanism of vitamin D signaling that regulates calcium homeostasis and should be re-evaluated to account for vitamin D signaling mechanisms in the immune system.</p>}, month = {1}, keywords = {ASL R2601}, issn = {2693-0293}, publisher={Iowa State University Digital Press}, journal = {Iowa State University Animal Industry Report} }