Dairy

Regulation of Immune Responses to Mycobacteria bovis by a Paracrine Mechanism of Vitamin D Signaling in Cattle

Authors: Corwin D. Nelson (Iowa State University) , Donald C. Beitz (Iowa State University) , Timothy A. Reinhardt (United States Department of Agriculture) , John D. Lippolis (United States Department of Agriculture)

Abstract

We provide evidence that T-cell responses to Mycobacteria bovis are suppressed by the production of 1,25-dihydroxyvitamin D₃ in monocytes and B-cells from cattle. Current vitamin D requirements for cattle are solely based on the classical endocrine mechanism of vitamin D signaling that regulates calcium homeostasis and should be re-evaluated to account for vitamin D signaling mechanisms in the immune system.

Keywords: ASL R2601

How to Cite: Nelson, C. D. , Beitz, D. C. , Reinhardt, T. A. & Lippolis, J. D. (2011) “Regulation of Immune Responses to Mycobacteria bovis by a Paracrine Mechanism of Vitamin D Signaling in Cattle”, Iowa State University Animal Industry Report. 8(1). doi: https://doi.org/10.31274/ans_air-180814-646