Prenatal and Postnatal Dietary n-3 Fatty Acid Supplementation Alters Buffy Coat DNA Methylation Profile in Pigs
- Rebecca Boddicker (Iowa State University)
- James Koltes (Iowa State University)
- Eric Fritz (Iowa State University)
- Venkatesh Mani (Iowa State University)
- James M. Reecy (Iowa State University)
- Lance H. Baumgard (Iowa State University)
- Nicholas K. Gabler (Iowa State University)
- Jason W. Ross (Iowa State University)
Abstract
The objective of this study was to determine the effect of maternal long chain n-3 fatty acid supplementation on the DNA methylation profile of offspring buffy coats. We demonstrated several methylated regions across the genome were influenced by maternal n-3 dietary treatment. Therefore, feeding n-3 fatty acids to sows during gestation and lactation may result in a DNA methylation imprint on offspring buffy coats that persists beyond the nursery phase and may alter the phenotype of the growing pig.
Keywords: ASL R2741
How to Cite:
Boddicker, R., Koltes, J., Fritz, E., Mani, V., Reecy, J. M., Baumgard, L. H., Gabler, N. K. & Ross, J. W., (2012) “Prenatal and Postnatal Dietary n-3 Fatty Acid Supplementation Alters Buffy Coat DNA Methylation Profile in Pigs”, Iowa State University Animal Industry Report 9(1). doi: https://doi.org/10.31274/ans_air-180814-194
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