Swine

Prenatal and Postnatal Dietary n-3 Fatty Acid Supplementation Alters Buffy Coat DNA Methylation Profile in Pigs

Authors
  • Rebecca Boddicker (Iowa State University)
  • James Koltes (Iowa State University)
  • Eric Fritz (Iowa State University)
  • Venkatesh Mani (Iowa State University)
  • James M. Reecy (Iowa State University)
  • Lance H. Baumgard (Iowa State University)
  • Nicholas K. Gabler (Iowa State University)
  • Jason W. Ross (Iowa State University)

Abstract

The objective of this study was to determine the effect of maternal long chain n-3 fatty acid supplementation on the DNA methylation profile of offspring buffy coats. We demonstrated several methylated regions across the genome were influenced by maternal n-3 dietary treatment. Therefore, feeding n-3 fatty acids to sows during gestation and lactation may result in a DNA methylation imprint on offspring buffy coats that persists beyond the nursery phase and may alter the phenotype of the growing pig.

Keywords: ASL R2741

How to Cite:

Boddicker, R., Koltes, J., Fritz, E., Mani, V., Reecy, J. M., Baumgard, L. H., Gabler, N. K. & Ross, J. W., (2012) “Prenatal and Postnatal Dietary n-3 Fatty Acid Supplementation Alters Buffy Coat DNA Methylation Profile in Pigs”, Iowa State University Animal Industry Report 9(1). doi: https://doi.org/10.31274/ans_air-180814-194

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Published on
01 Jan 2012
Peer Reviewed