Swine

Prenatal and Postnatal Dietary n-3 Fatty Acid Supplementation Alters Buffy Coat DNA Methylation Profile in Pigs

Authors: Rebecca Boddicker (Iowa State University) , James Koltes (Iowa State University) , Eric Fritz (Iowa State University) , Venkatesh Mani (Iowa State University) , James M. Reecy (Iowa State University) , Lance H. Baumgard (Iowa State University) , Nicholas K. Gabler (Iowa State University) , Jason W. Ross (Iowa State University)

Abstract

The objective of this study was to determine the effect of maternal long chain n-3 fatty acid supplementation on the DNA methylation profile of offspring buffy coats. We demonstrated several methylated regions across the genome were influenced by maternal n-3 dietary treatment. Therefore, feeding n-3 fatty acids to sows during gestation and lactation may result in a DNA methylation imprint on offspring buffy coats that persists beyond the nursery phase and may alter the phenotype of the growing pig.

Keywords: ASL R2741

How to Cite: Boddicker, R. , Koltes, J. , Fritz, E. , Mani, V. , Reecy, J. M. , Baumgard, L. H. , Gabler, N. K. & Ross, J. W. (2012) “Prenatal and Postnatal Dietary n-3 Fatty Acid Supplementation Alters Buffy Coat DNA Methylation Profile in Pigs”, Iowa State University Animal Industry Report. 9(1). doi: https://doi.org/10.31274/ans_air-180814-194