Synergism between Porcine Reproductive and Respiratory

  • Robert W. Wills (University of Nebraska–Lincoln)
  • Paula Fedorka-Cray (United States Department of Agriculture)
  • Kyoung-Jin Yoon (Iowa State University)
  • Jeffery T. Gray (University of Osteopathic Medicine and Health Sciences)
  • Tom J. Stabel (United States Department of Agriculture)
  • Jeffrey J. Zimmerman (Iowa State University)


This study was conducted to investigate the effects of exposure to porcine reproductive and respiratory syndrome virus, Salmonella choleraesuis, and stress on young swine. Five-week-old segregated early weaned pigs were randomly assigned to one of eight treatments consisting of all possible combinations of three factors: S. choleraesuis (SC) on day zero, porcine reproductive and respiratory syndrome virus (PRRSV) on day three, and dexamethasone (DEX) on days three to seven. DEX was used as a proxy for stress. Treatment differences were seen in performance parameters, levels and duration of SC shedding, level and distribution of SC in tissues, clinical disease, and mortality. The results of this study provided evidence to support field observations that clinical outbreaks of PRRS are the result of interactions among concurrent infections and stressors.

Keywords: ASL R1406

How to Cite:

Wills, R. W., Fedorka-Cray, P., Yoon, K., Gray, J. T., Stabel, T. J. & Zimmerman, J. J., (1997) “Synergism between Porcine Reproductive and Respiratory”, Iowa State University Animal Industry Report 1(1).

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Published on
01 Jan 1997
Peer Reviewed