Animal Health

1,25-Dihydroxyvitamin D3 Enhances Bovine Mammary Epithelial Innate Immune Responses

  • Corwin Nelson (Iowa State University)
  • Donald C. Beitz (Iowa State University)
  • Timothy A. Reinhardt (United States Department of Agriculture)
  • John Lippolis (United States Department of Agriculture)


Bovine mammary epithelial cells that were treated with bacterial lipopolysaccharide and 1,25-dihydroxyvitamin D3 showed an increase in the expression of the genes for inducible nitric oxide synthase (iNOS) and S100 calcium binding protein A12 (S100 A12). iNOS and S100 A12 are part of the innate immune response and expressed in the mammary gland during mastitis. Production of 1,25- dihydroxyvitamin D3 in the mammary gland during mastitis, then, may be an important component of the innate immune response.

Keywords: ASL R2488

How to Cite:

Nelson, C., Beitz, D. C., Reinhardt, T. A. & Lippolis, J., (2010) “1,25-Dihydroxyvitamin D3 Enhances Bovine Mammary Epithelial Innate Immune Responses”, Iowa State University Animal Industry Report 7(1). doi:

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Published on
01 Jan 2010
Peer Reviewed