Topical Flunixin Meglumine Effects on Pain Associated Biomarkers after Dehorning

  • Michael D. Kleinhenz (Iowa State University)
  • Nicholas K. Van Engen (Iowa State University)
  • Patrick J. Gorden (Iowa State University)
  • Johann F. Coetzee (Iowa State University)


Twenty-four calves were dehorned and treated with either topical flunixin meglumine formulated for systemic absorption or a placebo. Biomarkers associated with pain were evaluated for up to 72 hour after the dehorning procedure. Plasma cortisol concentrations, 90 minutes post-dehorning, and mechanical nociception threshold at the control site were the only tested biomarkers where a significant difference was demonstrated. No other differences of biomarkers between the two dehorned groups were observed for any time points. Although this product is easy to dose and dispense, its effects on pain biomarkers appears to be negligible.

Keywords: Veterinary Diagnostic and Production Animal Medicine

How to Cite:

Kleinhenz, M. D., Van Engen, N. K., Gorden, P. J. & Coetzee, J. F., (2016) “Topical Flunixin Meglumine Effects on Pain Associated Biomarkers after Dehorning”, Iowa State University Animal Industry Report 13(1). doi: https://doi.org/10.31274/ans_air-180814-217

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Published on
01 Jan 2016
Peer Reviewed