Animal Health

Immunization of Swine with Virus-like Replicon Particles: Proof of Concept

  • Matthew M. Erdman (Iowa State University)
  • Brenda G. Crabtree (Iowa State University)
  • D.L. Hank Harris (Iowa State University)
  • Kurt I. Kamrud (AlphaVax, Inc.)


Pigs were inoculated with virus-like replicon particle (VRP) vaccines expressing the influenza hemagglutinin (HA) protein. A robust antibody response was present following the inoculation. These results indicate that VRP vaccines can successfully express a foreign antigen in the pig and induce high antibody titers. This proof of concept work supports the further in vivo evaluation of VRP expressing swine influenza virus (SIV) HA protein as well as VRP co-expressing porcine reproductive and respiratory syndrome virus (PRRSV) GP5 and M proteins as novel vaccines for swine.

Keywords: ASL R2174

How to Cite:

Erdman, M. M., Crabtree, B. G., Harris, D. H. & Kamrud, K. I., (2007) “Immunization of Swine with Virus-like Replicon Particles: Proof of Concept”, Iowa State University Animal Industry Report 4(1). doi:

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Published on
01 Jan 2007
Peer Reviewed