Different Genetic Resistance Resulted in Distinct Response to Newcastle Disease Virus

  • Jibin Zhang (Iowa State University)
  • Michael G. Kaiser (Iowa State University)
  • Melissa S. Herrmann (Iowa State University)
  • Rodrigo A. Gallardo (University of California, Davis)
  • David A. Bunn (University of California, Davis)
  • Terra R. Kelly (University of California, Davis)
  • Jack C. M. Dekkers (Iowa State University)
  • Huaijun Zhou (Iowa State University)
  • Susan J. Lamont (Iowa State University)


As one of the most severe infectious diseases in the poultry industry, Newcastle disease (ND) causesa significant economic loss worldwideeven with the extensive implementation of vaccine. Tofind targets to improvegenetic resistance to NDto enhanceprotection in chickens, gene expression was analyzedin spleen of two chickenlines which differed in their resistanceto ND. The comparison of gene expression between two treatments(challenged or non-challenged)inthe two chicken lines at 2 and 6 days post-inoculation (dpi) suggeststhat thatt he mostdramatic changes ofgene expression occurredin Leghorn chickens at 2dpi.Theidentifieddifferentially expressed genesthat regulatesplenicresponse toNDVprovidepotential avenuestobreedNDV-resistantchickens in the future.

How to Cite:

Zhang, J., Kaiser, M. G., Herrmann, M. S., Gallardo, R. A., Bunn, D. A., Kelly, T. R., Dekkers, J. C., Zhou, H. & Lamont, S. J., (2017) “Different Genetic Resistance Resulted in Distinct Response to Newcastle Disease Virus”, Iowa State University Animal Industry Report 14(1). doi: https://doi.org/10.31274/ans_air-180814-324

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Published on
01 Jan 2017
Peer Reviewed