The Effect of PRRS Viral Level and Isolate on Tonsil Gene Expression

  • Qian Dong (Iowa State University)
  • Joan Lunney (United States Department of Agriculture)
  • Elyn Fritz-Waters (Iowa State University)
  • Yet Nguyen (Iowa State University)
  • Bob Rowland (Kansas State University)
  • Andrew S. Hess (Iowa State University)
  • James M. Reecy (Iowa State University)
  • Jack C. M. Dekkers (Iowa State University)


Porcine Reproductive and Respiratory Syndrome virus (PRRSV) can persist in tonsil tissue for >150 days post infection (dpi) without clinical signs.This can occur even when PRRSV is cleared from serumand can result insecondary outbreaks. Tonsil tissue from commercial crossbred pigs that were experimentally infected with one of two PRRSV isolates, NVSL-97-7985 (NVSL) or KS-2006-72109 (KS06),was used to identify genes that were differentially expressed in pigs with extreme high or low tonsil PRRS viremia at 42 dpi. Results provide insighton the mechanisms of PRRSV persistence in tonsils and help to identify bio-markers for PRRSV persistence in tonsil tissue.This maylead tothe development of more effective strategies to reduce the chance of PRRS re-breaks.

How to Cite:

Dong, Q., Lunney, J., Fritz-Waters, E., Nguyen, Y., Rowland, B., Hess, A. S., Reecy, J. M. & Dekkers, J. C., (2017) “The Effect of PRRS Viral Level and Isolate on Tonsil Gene Expression”, Iowa State University Animal Industry Report 14(1). doi: https://doi.org/10.31274/ans_air-180814-299

Download pdf



Published on
01 Jan 2017
Peer Reviewed