Sheep & Goats

Single-step GWAS identifies candidate genes associated with feed efficiency in Corriedale sheep

---

Abstract

The objective of this study was to identify genomic regions and candidate genes associated with dry matter intake (DMI), residual feed intake (RFI), feed conversion ratio (FCR), average daily gain (ADG), metabolic body weight (MBW), and methane emissions (ME) in Corriedale sheep. Phenotypic records were available for 581 animals for DMI, FCR, ADG, and MBW; for 569 animals for RFI; and for 522 animals for ME. Genotypes were obtained using the Applied Biosystems™ Axiom™ Ovine Genotyping Array 50K for 511-522 animals, depending on the trait. SNP effects were estimated from genomic estimated breeding values (GEBVs) using a single-step genome-wide association study (ssGWAS). Genome-wide significance was determined using a Bonferroni-corrected threshold (p < 0.05), and genes located within ±50 kb of significant SNPs were considered candidate genes. Significant genomic regions were identified for RFI (22 SNPs), FCR (1 SNP), and ADG (21 SNPs), while no significant associations were detected for DMI, MBW, or ME. This resulted in 26, 1, and 16 candidate genes for RFI, FCR, and ADG, respectively. Functional enrichment analysis was performed for RFI and ADG. For RFI, only one enriched term was detected (GO:0110016, B-WICH complex), involving the candidate genes MYBBP1A and ERCC6. No enriched terms were identified for ADG, and enrichment analysis was not performed for FCR due to the presence of only one candidate gene. Candidate genes for RFI include MYBBP1A and ERCC6, involved in chromatin remodeling and DNA repair; RORA, a nuclear receptor; and SPNS2, a sphingolipid transporter. For FCR, the single gene GALNT3 encodes a polypeptide N-acetylgalactosaminyltransferase involved in protein glycosylation. For ADG, candidate genes include SORT1 (protein sorting), PCCA (energy metabolism), PDE1C (cyclic nucleotide signaling), and MAGI2 (signal transduction). This study reveals genomic regions and candidate genes that may contribute to variation in feed efficiency traits in Corriedale sheep.

Keywords: 2026

How to Cite:

Carracelas, B., De Barbieri, I., Navajas, E., Guillenea, A., Aguilar, I. & Ciappesoni, G., (2026) “Single-step GWAS identifies candidate genes associated with feed efficiency in Corriedale sheep”, World Congress on Genetics Applied to Livestock Production Digital Archive 2026(1): 2286412. doi: https://doi.org/10.31274/wcgalp.23992

Rights: 1