Resistance to Colistin and Production of Extended-Spectrum β-Lactamases and/or AmpC Enzymes in Salmonella Isolates Collected from Pigs in NW Spain between 2008 and 2009
- A. Sevilla (Universidad de Zaragoza)
- B. González-Zorn (Universidad Complutense de Madrid)
- I Martín-Burriel (Universidad de Zaragoza)
- J. F. Delgado-Blas (Universidad Complutense de Madrid)
- J. P. Vico (Universidad Católica de Córdoba)
- R. Bolea (Universidad de Zaragoza)
- R. C. Mainar-Jaime (Universidad de Zaragoza)
Abstract
In the pig industry, the nursery is a critical production period as piglets are susceptible to a variety of enteric infections after weaning, and antimicrobials are commonly used as prophylactics to control Gram-negative (GN) infections. Colistin has been traditionally used to prevent post-weaning diarrhoea. Until recently, prevalence of colistin resistance (CR) was considered low and associated with chromosomal mutations of pmrA and pmrB genes (Adams et al., 2009). The recent detection and spread of new plasmid-mediated CR-associated genes (Lima et al., 2019), prompted the WHO in 2017 to declare colistin as a ´reserve´ drug against multidrug resistant (MDR) infections in human. In 2015, its use as prophylactic had been banned in Europe. In Spain, the use of colistin remained high (31.4 mg/ PCU) until 2015. In that year, a voluntary plan to reduce colistin use in pigs resulted in a significant drop in colistin use (9 mg/PCU)[1].
How to Cite:
Sevilla, A., González-Zorn, B., Martín-Burriel, I., Delgado-Blas, J. F., Vico, J. P., Bolea, R. & Mainar-Jaime, R. C., (2019) “Resistance to Colistin and Production of Extended-Spectrum β-Lactamases and/or AmpC Enzymes in Salmonella Isolates Collected from Pigs in NW Spain between 2008 and 2009”, SafePork 13(1), 69–70. doi: https://doi.org//safepork.11179
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