Health

Experimental Inoculation of Growing Pigs with U.S. Strains of Swine and Human Hepatitis E Viruses

Authors: Patrick G. Halbur (Iowa State University) , C. Kasorndorkbua (Iowa State University) , J. Bruna (Iowa State University) , R. Royer (Iowa State University) , R. H. Purcell (NIH Laboratory of Infectious Diseases) , S. U. Emerson (NIH Laboratory of Infectious Diseases) , X.-J. Meng (Virginia Polytechnic Institute and State University)

Abstract

U.S. strains of swine and human hepatitis E viruses (HEV) are closely related genetically. We found that swine and human HEV differ in virulence and both induce subclinical, but morphologically discernable, hepatitis in experimentally infected SPF pigs. Experimental inoculation of pigs with human HEV may provide a useful model to study the pathogenesis of hepatitis E virus infection and test efficacy of human HEV vaccines.

Keywords: ASL R1700

How to Cite: Halbur, P. G. , Kasorndorkbua, C. , Bruna, J. , Royer, R. , Purcell, R. H. , Emerson, S. U. & Meng, X. (2000) “Experimental Inoculation of Growing Pigs with U.S. Strains of Swine and Human Hepatitis E Viruses”, Iowa State University Animal Industry Report. 1(1).