Beef

Toll-Like Receptor Signaling in Bovine Macrophages Increases 1,25-Dihydroxyvitamin D3 Production

Authors: Corwin Nelson (Iowa State University) , Donald C. Beitz (Iowa State University) , Tim Reinhardt (United States Department of Agriculture) , John Lippolis (United States Department of Agriculture)

Abstract

Recognition of pathogen associated molecular patterns by Toll-like receptors (TLR) increases 1α-hydroxylase expression in bovine macrophages. This results in increased conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1,25- dihydroxyvitamin D3 (1,25(OH)2D3) in bovine macrophages. Production of 1,25(OH)2D3 in bovine macrophages indicates that 1,25(OH)2D3 may be involved in modulating the bovine immune response.

Keywords: ASL R2276

How to Cite: Nelson, C. , Beitz, D. C. , Reinhardt, T. & Lippolis, J. (2008) “Toll-Like Receptor Signaling in Bovine Macrophages Increases 1,25-Dihydroxyvitamin D3 Production”, Iowa State University Animal Industry Report. 5(1). doi: https://doi.org/10.31274/ans_air-180814-482