Poultry

Integration of Host and Virus Gene Expression for Chickens Response to Avian Leukosis Virus Challenge

Authors: Xi Lan (Iowa State University) , John C.F. Hsieh (Iowa State University) , Haibo Liu (Iowa State University) , Susan J. Lamont (Iowa State University) , Qing Zhu (Sichuan Agricultural University)

Abstract

The tumorigenesis caused by avian leukosis virus (ALV) occurs through a complex regulatory architecture. , We applied a novel methodology to jointly analyze four different types of datasets: mRNA expression, the associated regulatory factors of miRNA and lncRNA, and ALV gene expression. The pathway analysis shows that combined analysis produced more informative results than single data-type analyses, and the co-expression network analysis found key elements involved in the host-pathogen interaction. The integration of multiple data sources yielded deeper insights into the pathogenesis of the virus and the host immune response.

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How to Cite: Lan, X. , Hsieh, J. C. , Liu, H. , Lamont, S. J. & Zhu, Q. (2018) “Integration of Host and Virus Gene Expression for Chickens Response to Avian Leukosis Virus Challenge”, Iowa State University Animal Industry Report. 15(1). doi: https://doi.org/10.31274/ans_air-180814-388