Swine

Improvement of Lipid Absorption in Young Pigs as a Model for Preterm Infants

Authors
  • K. M. Carnagey (Iowa State University)
  • D. S. Lewis (California State Polytechnic University, Pomona)
  • J. W. Stewart (Iowa State University)
  • Donald C. Beitz (Iowa State University)

Abstract

Preterm infants and neonatal suckling piglets have a limited bile acid pool that may hinder absorption of dietary lipids such as fatty acids, triacylglycerols (TAGs), and other lipid-soluble nutrients. Because dietary lipids are a valuable source of energy for growth, it is important that they are efficiently absorbed. The hypothesis of this study is that oral administration of 0.2 g/kg body weight daily of cholylsarcosine, an artificial bile acid, would decrease fecal excretion of dietary fatty acids and TAGs in suckling piglets. Twelve 7-d-old piglets were housed individually and fed a commercial milk replacer with or without oral cholylsarcosine until 21 d of age. Cholylsarcosine treatment decreased fecal excretion of stearic acid (18:0) and palmitic acid (16:0) (P ≤ 0.02). Cholylsarcosine supplementation had no effect on absorption of unsaturated fatty acids of 16 or 18 carbons (P > 0.05). Cholylsarcosine increased fecal excretion of deoxycholic acid (P = 0.03). Apparent absorption of dietary TAGs was increased from 77% in piglets not fed cholylsarcosine to 83% in the piglets that received oral cholylsarcosine. These results support the hypothesis that cholylsarcosine increases absorption of dietary TAGs.

Keywords: ASL R1958

How to Cite:

Carnagey, K. M., Lewis, D. S., Stewart, J. W. & Beitz, D. C., (2004) “Improvement of Lipid Absorption in Young Pigs as a Model for Preterm Infants”, Iowa State University Animal Industry Report 1(1). doi: https://doi.org/10.31274/ans_air-180814-833

Downloads:
Download pdf

183 Views

65 Downloads

1Citations

Published on
01 Jan 2004
Peer Reviewed