Dairy

Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis

Authors
  • Patrick J. Gorden (Iowa State University)
  • Michael D. Kleinhenz (Iowa State University)
  • Larry W. Wulf (Iowa State University)
  • Butch KuKanich (Kansas State University)
  • Chang J. Lee (Iowa State University)
  • Chong Wang (Iowa State University)
  • Johann F. Coetzee (Iowa State University)

Abstract

Ceftiofur is the most commonly used antimicrobial in lactating dairy cows. Recently, there has been an increase in the number of violative residues of ceftiofur in the tissues of cull dairy cows. This was the first project in a series of projects we will be completing aimed at characterizing the pharmacokinetics of ceftiofur in disease challenged animals. The results of this study indicate that diseased animals have lower plasma concentrations and altered pharmacokinetics compared to healthy animals. Future work will investigate the influence of altered pharmacokinetics on the presence of violative residues.

Keywords: Veterinary Diagnostic and Production Animal Medicine

How to Cite:

Gorden, P. J., Kleinhenz, M. D., Wulf, L. W., KuKanich, B., Lee, C. J., Wang, C. & Coetzee, J. F., (2016) “Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis”, Iowa State University Animal Industry Report 13(1). doi: https://doi.org/10.31274/ans_air-180814-216

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Published on
01 Jan 2016
Peer Reviewed