Animal Health
Authors: Brad T. Bosworth (Iowa State University) , Matthew M. Erdman (Iowa State University) , Christa Irwin (Iowa State University) , Alan T. Loynachan (Iowa State University) , D.L. Hank Harris (Iowa State University)
A major hurdle to swine influenza vaccination of young piglets is maternal antibody interference. This interference is transient as it disappears when pigs reach about 3 months of age. We vaccinated piglets without and with interfering maternal antibody using a recombinant vector vaccine. In the absence of interfering maternal antibody, the vaccine was effective in inducing a strong immune response and greatly reduced the amount of virus. However, this same recombinant vaccine was not effective when interfering maternal antibodies were present. We are currently trying a higher dose of vaccine and different genes from SIV in hopes we can overcome this maternal antibody. Preliminary data from these new studies are promising.
Keywords: ASL R2384
How to Cite: Bosworth, B. T. , Erdman, M. M. , Irwin, C. , Loynachan, A. T. & Harris, D. H. (2009) “Evaluation of a Virus-like Replicon Particle Vaccine Expressing Proteins of Swine Influenza Virus in Pigs With and Without Maternally Derived Antibodies”, Iowa State University Animal Industry Report. 6(1). doi: https://doi.org/10.31274/ans_air-180814-644