Animal Health

Evaluation of a Virus-like Replicon Particle Vaccine Expressing Proteins of Swine Influenza Virus in Pigs With and Without Maternally Derived Antibodies

Authors
  • Brad T. Bosworth (Iowa State University)
  • Matthew M. Erdman (Iowa State University)
  • Christa Irwin (Iowa State University)
  • Alan T. Loynachan (Iowa State University)
  • D.L. Hank Harris (Iowa State University)

Abstract

A major hurdle to swine influenza vaccination of young piglets is maternal antibody interference. This interference is transient as it disappears when pigs reach about 3 months of age. We vaccinated piglets without and with interfering maternal antibody using a recombinant vector vaccine. In the absence of interfering maternal antibody, the vaccine was effective in inducing a strong immune response and greatly reduced the amount of virus. However, this same recombinant vaccine was not effective when interfering maternal antibodies were present. We are currently trying a higher dose of vaccine and different genes from SIV in hopes we can overcome this maternal antibody. Preliminary data from these new studies are promising.

Keywords: ASL R2384

How to Cite:

Bosworth, B. T., Erdman, M. M., Irwin, C., Loynachan, A. T. & Harris, D. H., (2009) “Evaluation of a Virus-like Replicon Particle Vaccine Expressing Proteins of Swine Influenza Virus in Pigs With and Without Maternally Derived Antibodies”, Iowa State University Animal Industry Report 6(1). doi: https://doi.org/10.31274/ans_air-180814-644

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Published on
01 Jan 2009
Peer Reviewed