Animal Health

Passive Immunization of Piglets with Hyperimmune Plasma Containing Virus Neutralizing Antibodies to Porcine Reproductive and Respiratory Syndrome Virus

Authors: Laura Kaniewski (Iowa State University) , Jason Hocker (Iowa State University) , Mark Mogler (Iowa State University) , Matthew M. Erdman (Iowa State University) , Eric Nelson (South Dakota State University) , D.L. Hank Harris (Iowa State University)

Abstract

Polyvalent hyperimmune plasma (HP) with high-titers of virus neutralizing (VN) antibody to porcine reproductive and respiratory syndrome virus (PRRSV) strains was produced in gilts and used to passively immunize 3 week old piglets. The piglets were subsequently challenged with live virus. Results showed delay of viremia, decrease in live virus titers, decrease in gross lung lesions, or delay in transmission to naïve, non-immunized sentinel pigs.

Keywords: ASL R2380

How to Cite: Kaniewski, L. , Hocker, J. , Mogler, M. , Erdman, M. M. , Nelson, E. & Harris, D. H. (2009) “Passive Immunization of Piglets with Hyperimmune Plasma Containing Virus Neutralizing Antibodies to Porcine Reproductive and Respiratory Syndrome Virus”, Iowa State University Animal Industry Report. 6(1). doi: https://doi.org/10.31274/ans_air-180814-65