Animal Health

Replicon Particle Administration Prior to Challenge Reduces PRRSV Viremia

Authors: Mark Mogler (Iowa State University) , Ryan Lee Vander Veen (Iowa State University) , Kurt I. Kamrud (Iowa State University) , D.L. Hank Harris (Iowa State University)

Abstract

Vaccination of swine with an alphavirus-derived replicon particle vaccine stimulates a non-specific immune response. This effect was seen when animals were challenged with PRRSV at 24 hours post-vaccination. Animals that received vaccine had reduced viremia as measured by quantitative RT-PCR when compared to placebo. These results highlight the potential of replicon particle vaccines to induce robust immune responses in swine.

Keywords: ASL R2674

How to Cite: Mogler, M. , Vander Veen, R. L. , Kamrud, K. I. & Harris, D. H. (2012) “Replicon Particle Administration Prior to Challenge Reduces PRRSV Viremia”, Iowa State University Animal Industry Report. 9(1). doi: https://doi.org/10.31274/ans_air-180814-172